HMP Shunt Biochemistry Medbullets Step 1 Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Pentose Phosphate Pathway ChemTalk Pentose Phosphate Pathway and Nicotinamide Adenine Dinucleotide Phosphate A metabolic switch to the pentose phosphate pathway induces radiation resistance in pancreatic cancer Radiotherapy and Oncology The pentose phosphate pathway in health and disease Nature Metabolism