Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Pathology Outlines Melanotic macule Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management ScienceDirect This is a very rare case of metastatic oral mucosal melanoma to the colon with an unusual presentation mimicking melanosis coli. The colonoscopy findings show no mass effect but multiple hyperpigmented lesions Diffuse pigmentation of the oral mucosa Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Pathology Outlines Oral mucosal melanoma