Homocysteine May Decrease Glucose Uptake and Alter the Akt GSK3 GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen Molecular Neurobiology Springer Nature Link Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. What To Avoid When Taking Glutathione Dose dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets Molecular and Cellular Biochemistry Springer Nature Link Current Insights into Glutathione Depletion in Adult Septic Patients Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine