Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Interaction with Ethanol Alcohol Metabolism Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Chronic Glutathione Depletion Confers Protection against Alcohol induced Steatosis: Implication for Redox Activation of AMP activated Protein Kinase Pathway Scientific Reports