Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. How Keeping Glutathione Levels Up Can Benefit Your Health & Your Vitamin D Status GrassrootsHealth Common Medications That Rob the Body of Nutrients Wellness Resources Gender specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen Scientific Reports How NSAIDs Affect Glutathione Levels Pure TheraPro Rx