Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Pigmented Lesions and Melanoma Plastic Surgery KeyPlastic Surgery Key Lenticular melanotic macule on the lower lip of a Laugier Hunziker Download Scientific Diagram This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Mara Ever wondered what those little brown spots are that are often found on the lip? Many refer to them as a freckle but the medical term is melanotic macules.