Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol Liver Damage Signs, Causes, Dosage, Stages & Prognosis