Tylenol And Glutathione Invigor Medical Tylenol And Glutathione Invigor Medical In vivo upstream factors of mouse hepatotoxic mechanism with sustained hepatic glutathione depletion: Acetaminophen metabolite erythrocyte adducts and splenic macrophage generated reactive oxygen species ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione: The Master Antioxidant Your Body Needs TRT Nation