Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram The Hidden Impact of Acetaminophen Well Rooted Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Did you know acetaminophen lowers glutathione levels? Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Dr. Laura E. Riley joined @GoodMorningAmerica recently to clear up some lingering confusion about Tylenol (acetaminophen) use during pregnancy. A new study from the University of London found that acetaminophen is safe