Oral Mucosal Melanosis IntechOpen Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Happy Wednesday! , In this video, a patients labial melanotic macule (a benign pigmented lesion) is being treated with liquid nitrogen. Labial melanotic macules are flat and asymmetrical with a QSwitched 785 nm laser in the treatment of labial melanotic macules Gallo 2024 Skin Research and Technology Wiley Online Library Oral Melanotic Macule: Symptoms and Treatment Skinsight PDF) Labial Melanotic Macule Diagnosed by Dermoscopy