Reactions of Amides a) Hydrolysis Amides can break back into the acid and amine when heated with: Strong acid Strong base Example: Amide + HO Carboxylic acid + Amine b) Reduction Mechanistic investigations of the hydrolysis of amides, oxoesters and thioesters via kinetic isotope effects and positional isotope exchange ScienceDirect Conformational analysis and enzyme activity: models for amide hydrolysis. Henry Rzepa's Blog Henry Rzepa's Blog Rapid amidic hydrolysis: a competitive reaction pathway under basic conditions for N (hydroxymethyl)benzamide derivatives bearing electron donating groups ScienceDirect Amide Activation in Ground and Excited States Selective Hydrolysis of Primary and Secondary Amides Enabled by Visible Light Organic Letters