Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Tylenol and Glutathione: A Closer Look At Their Relationship Acetaminophen Toxicity Poisoning