Can You Donate Blood If You Smoke? Cannabis, Nicotine, and More Severe bleeding linked to synthetic cannabinoid use Texas Poison Center Network Think you can't donate blood? Think again. Australian Red Cross Lifeblood We all know smoking and vaping isn't great for your health. But it doesn't stop you from being a blood or plasma donor. Just make sure to wait one hour after donating Smoking weed and plasma donation: are you eligible? Can You Donate Plasma If You Smoke Marijuana?